Transcriptomics: Lecture 1
Biotech 7005/Bioinf 3000
Frontiers of Biotechnology: Bioinformatics and Systems Modelling
The University of Adelaide
Frontiers of Biotechnology: Bioinformatics and Systems Modelling
The University of Adelaide
Welcome To Country
I’d like to acknowledge the Kaurna people as the traditional owners and custodians of the land we know today as the Adelaide Plains, where I live & work.
I also acknowledge the deep feelings of attachment and relationship of the Kaurna people to their place.
I pay my respects to the cultural authority of Aboriginal and Torres Strait Islander peoples from other areas of Australia, and pay our respects to Elders past, present and emerging, and acknowledge any Aboriginal Australians who may be with us today
Introduction
- Postdoctoral Bioinformatician, Black Ochre Data Labs, Adelaide
- Working in collaboration with members of the SA Aboriginal community
- Multi-omics project to identify and address the underlying causes of high T2D rates and complications
- Using genomics, epigenomics, transcriptomics and other layers
- My focus is on the transcriptomics layer
Why Transcriptomics?
- DNA can be described as being like a giant book of instructions
- Some regions are defined as genes
- Originally considered to be the basic unit of inheritance
- Now commonly used to describe a region of DNA transcribed into RNA
By Thomas Shafee - Own work, CC BY 4.0, Wikimedia Link
References
Fang, Rui, Walter N Moss, Michael Rutenberg-Schoenberg, and Matthew D Simon. 2015. “Probing Xist RNA Structure in Cells Using Targeted Structure-Seq.” PLoS Genet. 11 (12): e1005668.
Wang, Zhong, Mark Gerstein, and Michael Snyder. 2009. “RNA-Seq: A Revolutionary Tool for Transcriptomics.” Nat. Rev. Genet. 10 (1): 57–63.